Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.

Cancer immunology, immunotherapy : CII - 1 Jul 2022

Gneo Luciana, Rizkalla Nagy, Hejmadi Rahul, Mussai Francis, de Santo Carmela, Middleton Gary

Abstract excerpt

BACKGROUND: Monocytic myeloid-derived suppressor cells (M-MDSCs) are significantly expanded in the blood of colorectal cancer (CRC) patients. However, their presence and underlying mechanisms in the tumour microenvironment of CRC have not been examined in detail. METHODS: Tumour tissues and peripheral blood from CRC patients were analysed for the presence of M-MDSCs. The mechanisms of suppression were analysed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-10

Share to Monocytes

Share to Myeloid-Derived Suppressor Cells

Share to Phenotype

Share to Transforming Growth Factor beta

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34727230
DOI: 10.1007/s00262-021-03081-5
PMCID: PMC9188538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.PMID 34727230Read ↗

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtypeSemantic proximity Read ↗

Myeloid-Derived Suppressor Cells in Colorectal CancerSemantic proximity Read ↗

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancerSemantic proximity Read ↗

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancerSemantic proximity Read ↗

Immunophenotypic changes in peripheral blood of colorectal cancer patients: a potential diagnostic marker for CD4+ monocytesSemantic proximity Read ↗

Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer.Semantic proximity Read ↗

RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppressionSemantic proximity Read ↗

Ovarian Cancer Cells Direct Monocyte Differentiation Through A Non-Canonical PathwaySemantic proximity Read ↗

TGF-β type I receptor inhibitor suppresses polarization of tumor-associated macrophages to the M2 phenotype and exerts antitumor effects on colorectal cancerSemantic proximity Read ↗

Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment.Semantic proximity Read ↗

Dampened inflammatory signalling and myeloid-derived suppressor-like cell accumulation reduces circulating monocytic HLA-DR density and associates with malignancy risk in long-term renal transplant recipientsSemantic proximity Read ↗

Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.