Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment.

doi:10.1136/jitc-2020-002297

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Article

Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment.

Journal for immunotherapy of cancer - 1 Apr 2021

Väyrynen Juha P, Haruki Koichiro, Väyrynen Sara A, Lau Mai Chan, Dias Costa Andressa, Borowsky Jennifer, Zhao Melissa, Ugai Tomotaka, Kishikawa Junko, Akimoto Naohiko, Zhong Rong, Shi Shanshan, Chang Tzuu-Wang, Fujiyoshi Kenji, Arima Kota, Twombly Tyler S, Da Silva Annacarolina, Song Mingyang, Wu Kana, Zhang Xuehong, Chan Andrew T, Nishihara Reiko, Fuchs Charles S, Meyerhardt Jeffrey A, Giannakis Marios, Ogino Shuji, Nowak Jonathan A

Abstract excerpt

BACKGROUND: Myeloid cells represent an abundant yet heterogeneous cell population in the colorectal cancer microenvironment, and their roles remain poorly understood. METHODS: We used multiplexed immunofluorescence combined with digital image analysis to identify CD14+ monocytic and CD15+ granulocytic cells and to evaluate their maturity (HLA-DR and CD33), immunosuppressive potential (ARG1) and proximity to...

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Identifiers

PMID: 33931472
DOI: 10.1136/jitc-2020-002297
PMCID: PMC8098931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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