Article
Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer.
Journal of translational medicine - 1 Feb 2015
OuYang Li-Ying, Wu Xiao-Jun, Ye Shu-Biao, Zhang Rong-Xin, Li Ze-Lei, Liao Wei, Pan Zhi-Zhong, Zheng Li-Min, Zhang Xiao-Shi, Wang Zhong, Li Qing, Ma Gang, Li Jiang
Abstract excerpt
BACKGROUND: Expansions of myeloid-derived suppressor cells (MDSCs) have been identified in human solid tumors, including colorectal cancer (CRC). However, the nature of these tumor-associated MDSCs and their interactions with tumor cells in CRC are still poorly understood. METHODS: The percentages and phenotype of MDSCs in peripheral blood and tumorous and paraneoplastic tissues from CRC patients, as well as the...
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