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Article

Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis.

Anti-cancer drugs - 1 Jan 2022

Han Ji Min, Choi Kyung Hee, Lee Hong Hyun, Gwak Hye Sun

Abstract excerpt

Reports on the association between the solute carrier organic anion transporter 1B1 (SLCO1B1) T521C polymorphism and methotrexate-induced hepatotoxicity in patients with malignancies are inconsistent. This meta-analysis evaluated the association between the SLCO1B1 T521C polymorphism and methotrexate-induced hepatotoxicity. We performed a systematic review of previous reports from the PubMed, Web of Science, and...

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Topics

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Share to Antimetabolites, Antineoplastic
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Liver-Specific Organic Anion Transporter 1

Share to Methotrexate

Share to Neoplasms

Share to Polymorphism, Genetic

Share to Randomized Controlled Trials as Topic

Source

Identifiers

PMID: 34726639
DOI: 10.1097/CAD.0000000000001125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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