Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transporter Genes and statin-induced Hepatotoxicity.

Cardiovascular drugs and therapy - 1 Aug 2025

Choi Seo-A, Kim Jung Sun, Park Yoon-A, Lee Da Hoon, Park Minju, Yee Jeong, Chang Yoonkyung, Song Tae-Jin, Gwak Hye Sun

Abstract excerpt

PURPOSE: Hepatotoxicity has emerged as a major cause of statin treatment interruption. Although organic anion-transporting polypeptide 1B1 (SLCO1B1), multidrug resistance protein 1 (ABCB1), and breast cancer resistance protein (ABCG2) have been identified as transporters of statins, knowledge of their role in statin-associated hepatotoxicity remains limited. Therefore, we aimed to conduct a comprehensive analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Liver-Specific Organic Anion Transporter 1

Share to Neoplasm Proteins

Share to Pharmacogenomic Variants

Share to Risk Assessment

Source

Identifiers

PMID: 38809397
DOI: 10.1007/s10557-024-07580-2

Genes

SLCO1B1
ABCG2
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transporter Genes and statin-induced Hepatotoxicity.PMID 38809397Read ↗

Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of StatinsSemantic proximity Read ↗

Association Between ABCG2 Polymorphism and Statin-Induced Adverse Events: A Meta-Analysis.Semantic proximity Read ↗

Liver and Statins: A Critical Appraisal of the Evidence.Semantic proximity Read ↗

The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.Semantic proximity Read ↗

An update on efflux and uptake transporters as determinants of statin response.Semantic proximity Read ↗

Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1).Semantic proximity Read ↗

Effects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemia.Semantic proximity Read ↗

Pharmacogenetics of membrane transporters: a review of current approaches.Semantic proximity Read ↗

Genetic Polymorphisms of SLCO1B1, CYP2E1 and UGT1A1 and Susceptibility to Anti-Tuberculosis Drug-Induced Hepatotoxicity: A Chinese Population-Based Prospective Case-Control Study.Semantic proximity Read ↗

Loss of function polymorphisms in SLCO1B1 (c.521T>C, rs4149056) and ABCG2 (c.421C>A, rs2231142) genes are associated with adverse events of rosuvastatin: a case-control study.Semantic proximity Read ↗

The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins.Semantic proximity Read ↗

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.