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Article

CAMSAP3 depletion induces lung cancer cell senescence-associated phenotypes through extracellular signal-regulated kinase inactivation.

Cancer medicine - 1 Dec 2021

Wattanathamsan Onsurang, Chetprayoon Paninee, Chantaravisoot Naphat, Wongkongkathep Piriya, Chanvorachote Pithi, Pongrakhananon Varisa

Abstract excerpt

BACKGROUND: Cellular senescence is an aging-related process found in cancer cells that contributes to irreversible growth arrest and tumor aggressiveness. Recently, calmodulin-regulated spectrin-associated protein 3 (CAMSAP3), a minus-end microtubule-stabilizing protein, has received increasing attention in cancer cell biology. However, the biological role of CAMSAP3 on senescence in human lung cancer remains...

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Identifiers

PMID: 34724356
DOI: 10.1002/cam4.4380
PMCID: PMC8683528

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