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Article

Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

24 Aug 2021

Abstract excerpt

Cellular senescence acts as a potent tumor-suppression mechanism in mammals; however, it also promotes tumor progression in a non-cell-autonomous manner. We provided insights into the mechanism underlying senescence-dependent metastatic cancer development. The elimination of senescent cells suppressed the lung metastasis of melanoma cells. Using an antibody array screening of humoral factor(s) that depend on...

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Share to Epigenetics and DNA Methylation
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PMID: 34522864
DOI: 10.1016/j.isci.2021.103022

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