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Maspin Expression Is Transactivated by p63 and Is Critical for the Modulation of Lung Cancer Progression

1 Oct 2004

Abstract excerpt

Maspin inhibits metastasis of some cancer cells, and clinical studies have identified correlations between maspin loss and poor prognosis in several cancer types. Maspin was found to be significantly overexpressed in lung cancer samples as compared with matched normal lung tissues. However, the regulatory mechanism of maspin expression remains unclear. We show here that differential expression of maspin in...

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PMID: 15466179
DOI: 10.1158/0008-5472.can-04-1657

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