Article
Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus.
eLife - 30 May 2018
Lambert Francois M, Cardoit Laura, Courty Elric, Bougerol Marion, Thoby-Brisson Muriel, Simmers John, Tostivint Hervé, Le Ray Didier
Abstract excerpt
In vertebrates, functional motoneurons are defined as differentiated neurons that are connected to a central premotor network and activate peripheral muscle using acetylcholine. Generally, motoneurons and muscles develop simultaneously during embryogenesis. However, during Xenopus metamorphosis, developing limb motoneurons must reach their target muscles through the already established larval cholinergic axial...
Topics
- Acetylcholine
- Animals
- Choline O-Acetyltransferase
- Extremities
- Gene Expression Regulation, Developmental
- Metamorphosis, Biological
- Motor Activity
- Motor Neurons
- Muscle, Skeletal
- Neurotransmitter Agents
- Phenotype
- RNA, Messenger
- Spinal Cord