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Article

Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families.

World journal of gastroenterology - 7 Oct 2021

Hsieh Ai-Ru, Fann Cathy S J, Lin Hung-Chun, Tai Jennifer, Hsieh Sen-Yung, Tai Dar-In

Abstract excerpt

BACKGROUND: Genome-wide association studies from Asia indicate that HLA-DP and HLA-DQ loci are important in persistent hepatitis B virus (HBV) infections. One of the key elements for HBV-related carcinogenesis is persistent viral replication and inflammation. AIM: To examine genetic and nongenetic factors with persistent HBV infection and viral load in families with hepatocellular carcinoma (HCC). METHODS: The...

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Identifiers

PMID: 34712031
DOI: 10.3748/wjg.v27.i37.6262
PMCID: PMC8515798

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