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Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity

28 Oct 2021

Abstract excerpt

Disease progression and therapeutic resistance of prostate cancer (PC) are linked to multiple molecular events that promote survival and plasticity. We previously showed that heat shock protein 27 (HSP27) acted as a driver of castration-resistant phenotype (CRPC) and developed an oligonucleotides antisense (ASO) against HSP27 with evidence of anti-cancer activity in men with CRPC. Here, we show that the tumor...

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PMID: 34711954
DOI: 10.1038/s41388-021-02039-2

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