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Article

Targeting TCTP as a New Therapeutic Strategy in Castration-resistant Prostate Cancer

14 Aug 2012

Abstract excerpt

Heat shock protein 27 (Hsp27) is highly overexpressed in castration-resistant prostate cancer (CRPC) and an antisense inhibitor (OGX-427) is currently in phase II clinical trials. In order to understand mechanisms of action of Hsp27 and find new therapeutic targets specific of CRPC, we screened for Hsp27 client proteins. Here, we report that translationally controlled tumor protein (TCTP) is a new Hsp27 client...

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PMID: 22893039
DOI: 10.1038/mt.2012.155

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