Article
The long noncoding RNA HORAS 5 mediates castration‐resistant prostate cancer survival by activating the androgen receptor transcriptional program
18 Feb 2019
Abstract excerpt
Prostate cancer (PCa) is driven by the androgen receptor (AR)-signaling axis. Hormonal therapy often mitigates PCa progression, but a notable number of cases progress to castration-resistant PCa (CRPC). CRPC retains AR activity and is incurable. Long noncoding RNA (lncRNA) represent an uncharted region of the transcriptome. Several lncRNA have been recently described to mediate oncogenic functions, suggesting...
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