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Article

Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells

27 Oct 2021

Abstract excerpt

The HIV-1 envelope glycoprotein (Env) mediates viral entry into the host cell. Although the highly dynamic nature of Env intramolecular conformations has been shown with single molecule spectroscopy in vitro, the bona fide Env intra- and intermolecular mechanics when engaged with live T cells remains unknown. We used two photon fast fluorescence lifetime imaging detection of single-molecule Förster Resonance...

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PMID: 34707229
DOI: 10.1038/s42003-021-02658-1

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