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Article

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

8 Oct 2014

Abstract excerpt

The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores into variable regions of the glycoprotein gp120 subunit and measured single-molecule fluorescence resonance energy transfer within the context of native trimers on the surface of HIV-1 virions. Our observations revealed unliganded HIV-1 Env to be...

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PMID: 25298114
DOI: 10.1126/science.1254426

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