Article
Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission.
Nature cell biology - 1 Mar 2007
Sherer Nathan M, Lehmann Maik J, Jimenez-Soto Luisa F, Horensavitz Christina, Pypaert Marc, Mothes Walther
Abstract excerpt
The spread of retroviruses between cells is estimated to be 2-3 orders of magnitude more efficient when cells can physically interact with each other. The underlying mechanism is largely unknown, but transfer is believed to occur through large-surface interfaces, called virological or infectious synapses. Here, we report the direct visualization of cell-to-cell transmission of retroviruses in living cells. Our...
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