Article

Histone Methyltransferase WHSC1 Inhibits Colorectal Cancer Cell Apoptosis via Targeting Anti-apoptotic BCL2

2020-07-30

Abstract excerpt

<title>Abstract</title> <p>Background: WHSC1 is a histone methyltransferase that facilitates histone H3 lysine 36 dimethylation (H3K36me2), which is a permissive mark associated with active transcription. Colorectal cancer (CRC) is the 4th deadliest and 3rd most frequent cancer globally. However, the role of WHSC1 in CRC progression remains unknown. <h4>Methods:</h4> qRT-PCR, immunoblotting assays (WB), and immun...

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Literature Corpus work: 832af43e-ea62-5b18-a3df-f54dad83087b
DOI: 10.21203/rs.3.rs-35111/v2

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