Article
Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.
Circulation. Cardiovascular genetics - 1 Oct 2011
Schnabel Renate B, Kerr Kathleen F, Lubitz Steven A, Alkylbekova Ermeg L, Marcus Gregory M, Sinner Moritz F, Magnani Jared W, Wolf Philip A, Deo Rajat, Lloyd-Jones Donald M, Lunetta Kathryn L, Mehra Reena, Levy Daniel, Fox Ervin R, Arking Dan E, Mosley Thomas H, Müller-Nurasyid Martina, Young Taylor R, Wichmann H-Erich, Seshadri Sudha, Farlow Deborah N, Rotter Jerome I, Soliman Elsayed Z, Glazer Nicole L, Wilson James G, Breteler Monique M B, Sotoodehnia Nona, Newton-Cheh Christopher, Kääb Stefan, Ellinor Patrick T, Alonso Alvaro, Benjamin Emelia J, Heckbert Susan R
Abstract excerpt
BACKGROUND: The genetic background of atrial fibrillation (AF) in whites and African Americans is largely unknown. Genes in cardiovascular pathways have not been systematically investigated. METHODS AND RESULTS: We examined a panel of approximately 50,000 common single-nucleotide polymorphisms (SNPs) in 2095 cardiovascular candidate genes and AF in 3 cohorts with participants of European (n=18,524; 2260 cases) or...
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