Article
The role of rare variants in systolic blood pressure: analysis of ExomeChip data in HyperGEN African Americans.
Human heredity - 1 Jan 2015
Sung Yun Ju, Basson Jacob, Cheng Nuo, Nguyen Khanh-Dung H, Nandakumar Priyanka, Hunt Steven C, Arnett Donna K, Dávila-Román Victor G, Rao Dabeeru C, Chakravarti Aravinda
Abstract excerpt
Cardiovascular diseases are among the most significant health problems in the United States today, with their major risk factor, hypertension, disproportionately affecting African Americans (AAs). Although GWAS have identified dozens of common variants associated with blood pressure (BP) and hypertension in European Americans, these variants collectively explain <2.5% of BP variance, and most of the genetic...
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