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Article

Constraints for genetic association studies imposed by attributable fraction and familial risk.

Carcinogenesis - 1 Mar 2007

Hemminki Kari, Bermejo Justo Lorenzo

Abstract excerpt

Candidate gene studies have become very popular but some of their implicit constraints, such as the familial risk and the population attributable fraction (PAF) conferred by the gene under study, are poorly understood. We model here these parameters for susceptibility genes in terms of genotype relative risk (GRR), allele frequency and statistical power in simulated genetic association studies, assuming 500 or...

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Identifiers

PMID: 17012223
DOI: 10.1093/carcin/bgl182

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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