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Article

Prediction of warfarin dose reductions in Puerto Rican patients, based on combinatorial CYP2C9 and VKORC1 genotypes.

The Annals of pharmacotherapy - 1 Feb 2012

Valentin Isa Ivette, Vazquez Joan, Rivera-Miranda Giselle, Seip Richard L, Velez Meredith, Kocherla Mohan, Bogaard Kali, Cruz-Gonzalez Iadelisse, Cadilla Carmen L, Renta Jessica Y, Feliu Juan F, Ramos Alga S, Alejandro-Cowan Yirelia, Gorowski Krystyna, Ruaño Gualberto, Duconge Jorge

Abstract excerpt

BACKGROUND: The influence of CYP2C9 and VKORC1 polymorphisms on warfarin dose has been investigated in white, Asian, and African American populations but not in Puerto Rican Hispanic patients. OBJECTIVE: To test the associations between genotypes, international normalized ratio (INR) measurements, and warfarin dosing and gauge the impact of these polymorphisms on warfarin dose, using a published algorithm....

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Source

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Identifiers

PMID: 22274142
DOI: 10.1345/aph.1Q190
PMCID: PMC3378722

Genes

VKORC1

Provenance

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