Article
Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Apr 2013
Deelen Joris, Beekman Marian, Capri Miriam, Franceschi Claudio, Slagboom P Eline
Abstract excerpt
Human lifespan variation is mainly determined by environmental factors, whereas the genetic contribution is 25-30% and expected to be polygenic. Two complementary fields go hand in hand in order to unravel the mechanisms of biological aging: genomic and biomarker research. Explorative and candidate gene studies of the human genome by genetic, transcriptomic, and epigenomic approaches have resulted in the...
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