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Extended genetic analysis and tumor characteristics in over 4600 women with suspected hereditary breast and ovarian cancer.

BMC cancer - 10 Aug 2023

Öfverholm Anna, Törngren Therese, Rosén Anna, Arver Brita, Einbeigi Zakaria, Haraldsson Karin, Ståhlbom Anne Kinhult, Kuchinskaya Ekaterina, Lindblom Annika, Melin Beatrice, Paulsson-Karlsson Ylva, Stenmark-Askmalm Marie, Tham Emma, von Wachenfeldt Anna, Kvist Anders, Borg Åke, Ehrencrona Hans

Abstract excerpt

BACKGROUND: Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast and ovarian cancer (HBOC) has been attributed to PVs in the genes BRCA1 and BRCA2, and more recently other rare alleles have been firmly established as associated with a high or moderate...

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Identifiers

PMID: 37563628
DOI: 10.1186/s12885-023-11229-y
PMCID: PMC10413543

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