Article

Cellular Modeling of CLN6 with IPSC-derived Neurons and Glia

2024-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Neuronal ceroid lipofuscinosis (NCL), type 6 (CLN6) is a neurodegenerative disorder associated with progressive neurodegeneration leading to dementia, seizures, and retinopathy. CLN6 encodes a resident-ER protein involved in trafficking lysosomal proteins to the Golgi. CLN6p deficiency results in lysosomal dysfunction and deposition of storage material comprised of Nile Red + lipids/proteolipi...

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Literature Corpus work: 726677b0-2293-5738-9f63-cdf374551a84
DOI: 10.1101/2024.01.29.577876

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