Article
Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo.
Nature communications - 25 Oct 2021
Jann Johann-Christoph, Mossner Maximilian, Riabov Vladimir, Altrock Eva, Schmitt Nanni, Flach Johanna, Xu Qingyu, Nowak Verena, Obländer Julia, Palme Iris, Weimer Nadine, Streuer Alexander, Jawhar Ahmed, Darwich Ali, Jawhar Mohammad, Metzgeroth Georgia, Nolte Florian, Hofmann Wolf-Karsten, Nowak Daniel
Abstract excerpt
The bone marrow (BM) stroma in myeloid neoplasms is altered and it is hypothesized that this cell compartment may also harbor clonal somatically acquired mutations. By exome sequencing of in vitro expanded mesenchymal stromal cells (MSCs) from n = 98 patients with myelodysplastic syndrome (MDS) and n = 28 healthy controls we show that these cells accumulate recurrent mutations in genes such as ZFX (n = 8/98),...
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