MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates

Abstract excerpt

BACKGROUND: Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. MYCN encodes a transcription factor that requires dimerization with MAX to activate transcription of numerous target genes. MYCN gain has been associated with adverse prognosis in different childhood tumors including WT. The MYCN P44L and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to FOXO transcription factor regulation
• Share to Renal and related cancers
• Share to Renal cell carcinoma treatment