Article
Molecular characterization of Wilms' tumor from a resource-constrained region of sub-Saharan Africa.
International journal of cancer - 15 Sept 2012
Murphy Andrew J, Axt Jason R, de Caestecker Christian, Pierce Janene, Correa Hernan, Seeley Erin H, Caprioli Richard M, Newton Mark W, de Caestecker Mark P, Lovvorn Harold N
Abstract excerpt
Sub-Saharan African children have an increased incidence of Wilms' tumor (WT) and experience alarmingly poor outcomes. Although these outcomes are largely due to inadequate therapy, we hypothesized that WT from this region exhibits features of biological aggressiveness that may warrant broader implementation of high-risk therapeutic protocols. We evaluated 15 Kenyan WT (KWT) for features of aggressive disease...
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