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Article

MAX and MYC: A Heritable Breakup

17 Jun 2012

Abstract excerpt

The overexpression of MYC, which occurs in many tumors, dramatically disrupts the equilibrium between activation and repression of the oncogenic MYC/MYC-associated protein X (MAX)/MAX dimerization protein 1 (MXD1) network, favoring MYC-MAX complexes and thereby impairing differentiation and promoting cell growth. Although for some time it has appeared that MAX is necessary for both the activation and repression...

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PMID: 22706201
DOI: 10.1158/0008-5472.can-11-3891

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MAX and MYC: A Heritable BreakupPMID 22706201Read ↗

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