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Multi-region sequencing reveals genetic correlation between esophageal squamous cell carcinoma and matched cell-free DNA.

Cancer genetics - 1 Nov 2021

Yuan Zuyang, Wang Xinfeng, Geng Xiao, Li Yin, Tan Fengwei, Xue Qi, Gao Shugeng, He Jie

Abstract excerpt

PURPOSE: This study aimed to determine if both ubiquitous and heterogeneous somatic mutations could be detected in circulating cell-free DNA (cfDNA) in patients with esophageal squamous cell carcinoma (ESCC). METHODS: Paired multi-regional tumor tissues, cfDNA, and white blood cells (WBCs) were collected from five ESCC patients before treatment, as part of an ongoing prospective study (NCT02395705). Samples from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34688997
DOI: 10.1016/j.cancergen.2021.08.005

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