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Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study.

Gene - 30 Jan 2022

Usategui-Martín Ricardo, Pérez-Castrillón José Luis, Mansego María L, Lara-Hernández Francisco, Manzano Iris, Briongos Laisa, Abadía-Otero Jesica, Martín-Vallejo Javier, García-García Ana B, Martín-Escudero Juan Carlos, Chaves Felipe J

Abstract excerpt

The most widely accepted etiopathogenesis hypothesis of the origin of osteoporosis and its complications is that they are a consequence of bone aging and other environmental factors, together with a genetic predisposition. Evidence suggests that oxidative stress is crucial in bone pathologies associated with aging. The aim of this study was to determine whether genetic variants in oxidative stress-related genes...

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Identifiers

PMID: 34688818
DOI: 10.1016/j.gene.2021.146036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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