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Article

Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics.

Journal of hematology & oncology - 12 Sept 2023

Jin Hao-Ran, Wang Jin, Wang Zi-Jing, Xi Ming-Jia, Xia Bi-Han, Deng Kai, Yang Jin-Lin

Abstract excerpt

Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways of acquiring lipid and increasing lipid oxidation. In addition, stromal cells and immune cells in the tumor microenvironment also undergo lipid metabolic...

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Identifiers

PMID: 37700339
DOI: 10.1186/s13045-023-01498-2
PMCID: PMC10498649

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