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Article

Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.

Cells - 16 Mar 2023

Ostrovsky Olga, Beider Katia, Magen Hila, Leiba Merav, Sanderson Ralph D, Vlodavsky Israel, Nagler Arnon

Abstract excerpt

Multiple myeloma (MM) is a plasma cell malignancy that is accompanied by hypercalcemia, renal failure, anemia, and lytic bone lesions. Heparanase (HPSE) plays an important role in supporting and promoting myeloma progression, maintenance of plasma cell stemness, and resistance to therapy. Previous studies identified functional single nucleotide polymorphisms (SNPs) located in the HPSE gene. In the present study,...

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Source

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Identifiers

PMID: 36980254
DOI: 10.3390/cells12060913
PMCID: PMC10047783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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