Article

Short template switch events explain mutation clusters in the human genome

2016-02-01

Abstract excerpt

Resequencing efforts are uncovering the extent of genetic variation in humans and provide data to study the evolutionary processes shaping our genome. One recurring puzzle in both intra- and inter-species studies is the high frequency of complex mutations comprising multiple nearby base substitutions or insertion-deletions. We devised a generalized mutation model of template switching during replication that exten...

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Literature Corpus work: 58380af2-0d93-58ed-a4b0-fb080b34613f
DOI: 10.1101/038380

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