Article
FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation.
Molecular biology of the cell - 15 Jun 2020
Black Markaisa, Arumugam Paritha, Shukla Samriddhi, Pradhan Arun, Ustiyan Vladimir, Milewski David, Kalinichenko Vladimir V, Kalin Tanya V
Abstract excerpt
Forkhead box M1 (FOXM1), a nuclear transcription factor that activates cell cycle regulatory genes, is highly expressed in a majority of human cancers. The function of FOXM1 independent of nuclear transcription is unknown. In the present study, we found the FOXM1 protein inside the mitochondria. Using site-directed mutagenesis, we generated FOXM1 mutant proteins that localized to distinct cellular compartments,...
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