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Article

Allo-SCT for high-risk AML-CR1 in the molecular era: impact of FLT3/ITD outweighs the conventional markers.

Bone marrow transplantation - 1 Dec 2012

Sengsayadeth S M, Jagasia M, Engelhardt B G, Kassim A, Strickland S A, Goodman S, Lucid C, Vnencak-Jones C L, Greer J P, Savani B N

Abstract excerpt

Seventy-nine patients with AML in CR1 received allo-SCT between May 2006 and May 2011, and the prognostic impact of FMS-like tyrosine kinase 3/internal tandem duplication (FLT3/ITD) mutation was evaluated in the context of other clinical prognostic factors. Patients with FLT3/ITD + AML had significantly inferior DFS (2-year DFS: 19% vs 64%, P = 0.0027), increased risk of relapse (1-year: 59% vs 19%, P = 0.01),...

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Source

Identifiers

PMID: 22659680
DOI: 10.1038/bmt.2012.88

Genes

FLT3
SCT
CR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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