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Article

Genetic landscape of T cells identifies synthetic lethality for T-ALL.

Communications biology - 20 Oct 2021

O'Meara Connor P, Guerri Lucia, Lawir Divine-Fondzenyuy, Mateos Fernando, Iconomou Mary, Iwanami Norimasa, Soza-Ried Cristian, Sikora Katarzyna, Siamishi Iliana, Giorgetti Orlando, Peter Sarah, Schorpp Michael, Boehm Thomas

Abstract excerpt

To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in zebrafish were conducted and combined with genetic interaction analysis. After ENU mutagenesis, genetic lesions associated with failure of T cell development were identified by meiotic recombination mapping, positional cloning, and whole genome sequencing. Recessive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Source

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Identifiers

PMID: 34671088
DOI: 10.1038/s42003-021-02694-x
PMCID: PMC8528931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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