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Article

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia.

Haematologica - 1 Jan 2015

Bentley Victoria L, Veinotte Chansey J, Corkery Dale P, Pinder Jordan B, LeBlanc Marissa A, Bedard Karen, Weng Andrew P, Berman Jason N, Dellaire Graham

Abstract excerpt

Cancer therapeutics is evolving to precision medicine, with the goal of matching targeted compounds with molecular aberrations underlying a patient's cancer. While murine models offer a pre-clinical tool, associated costs and time are not compatible with actionable patient-directed interventions. Using the paradigm of T-cell acute lymphoblastic leukemia, a high-risk disease with defined molecular underpinnings,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25281505
DOI: 10.3324/haematol.2014.110742
PMCID: PMC4281315

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NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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