Article
Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development.
Cell reports - 22 Nov 2016
Iwanami Norimasa, Sikora Katarzyna, Richter Andreas S, Mönnich Maren, Guerri Lucia, Soza-Ried Cristian, Lawir Divine-Fondzenyuy, Mateos Fernando, Hess Isabell, O'Meara Connor P, Schorpp Michael, Boehm Thomas
Abstract excerpt
Lymphocytes represent basic components of vertebrate adaptive immune systems, suggesting the utility of non-mammalian models to define the molecular basis of their development and differentiation. Our forward genetic screens in zebrafish for recessive mutations affecting early T cell development revealed several major genetic pathways. The identification of lineage-specific transcription factors and specific...
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