Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural and engineered disorders of lymphocyte development.

Science (New York, N.Y.) - 10 Apr 1998

Fischer A, Malissen B

Abstract excerpt

Mammals have evolved complex developmental pathways to generate a large repertoire of B and T lymphocytes capable of mounting effective immune responses. Analysis of natural and engineered immunodeficiencies constitutes a powerful approach to delineating these pathways and identifying the molecular sensors that couple the survival of developing lymphocytes to the achievement of successful gene rearrangements at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Cytokines
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Signal Transduction

Share to T-Lymphocytes

Source

Identifiers

PMID: 9535646
DOI: 10.1126/science.280.5361.237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural and engineered disorders of lymphocyte development.PMID 9535646Read ↗

Cellular and molecular basis of immunodeficiencies: their consequences for the development and induction of the immune response.Semantic proximity Read ↗

Clinical consequences of defects in B-cell developmentSemantic proximity Read ↗

Molecular Regulation of Differentiation in Early B-Lymphocyte DevelopmentSemantic proximity Read ↗

Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development.Semantic proximity Read ↗

Primary immune deficiencies unravel the molecular basis of immune response.Semantic proximity Read ↗

Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the FutureSemantic proximity Read ↗

Tracing antigen-driven B cell development in humans.Semantic proximity Read ↗

Fates of human B-cell precursorsSemantic proximity Read ↗

Molecular regulation and dysregulation of T follicular helper cells - learning from inborn errors of immunity.Semantic proximity Read ↗

Human inborn errors of immunity: An expanding universeSemantic proximity Read ↗

Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.Semantic proximity Read ↗

Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.