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Article

Comprehensive methylation profile of CSF cfDNA revealed pathogenesis and diagnostic markers for early-onset Parkinson's disease.

Epigenomics - 1 Oct 2021

Meng Jie, Wang Fenglin, Ji Lei, Liang Yuhua, Nian Wei, Song Lele, Zhu Aiqin

Abstract excerpt

Background: Early-onset Parkinson's disease (EOPD) is one uncommon Parkinson's disease subtype with characteristic clinicopathological features. The full epigenomic profile of EOPD is largely unknown. Methods: We performed the first study to investigate the EOPD full methylation profile of cerebrospinal fluid (CSF) cell-free DNA (cfDNA) from 26 EOPD patients and 10 control patients. Results: 2220...

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Identifiers

PMID: 34664993
DOI: 10.2217/epi-2021-0176

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