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Article

Genetic and epigenetic characterization of posterior pituitary tumors

18 Oct 2021

Abstract excerpt

Pituicytoma (PITUI), granular cell tumor (GCT), and spindle cell oncocytoma (SCO) are rare tumors of the posterior pituitary. Histologically, they may be challenging to distinguish and have been proposed to represent a histological spectrum of a single entity. We performed targeted next-generation sequencing, DNA methylation profiling, and copy number analysis on 47 tumors (14 PITUI; 12 GCT; 21 SCO) to...

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PMID: 34661724
DOI: 10.1007/s00401-021-02377-1

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