Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.

doi:10.1007/s00401-019-02101-0

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Article

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.

Acta neuropathologica - 1 Feb 2020

Pfaff Elke, Aichmüller Christian, Sill Martin, Stichel Damian, Snuderl Matija, Karajannis Matthias A, Schuhmann Martin U, Schittenhelm Jens, Hasselblatt Martin, Thomas Christian, Korshunov Andrey, Rhizova Marina, Wittmann Andrea, Kaufhold Anna, Iskar Murat, Ketteler Petra, Lohmann Dietmar, Orr Brent A, Ellison David W, von Hoff Katja, Mynarek Martin, Rutkowski Stefan, Sahm Felix, von Deimling Andreas, Lichter Peter, Kool Marcel, Zapatka Marc, Pfister Stefan M, Jones David T W

Abstract excerpt

Tumors of the pineal region comprise several different entities with distinct clinical and histopathological features. Whereas some entities predominantly affect adults, pineoblastoma (PB) constitutes a highly aggressive malignancy of childhood with a poor outcome. PBs mainly arise sporadically, but may also occur in the context of cancer predisposition syndromes including DICER1 and RB1 germline mutation. With...

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PMID: 31768671
DOI: 10.1007/s00401-019-02101-0
PMCID: PMC7275775

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