Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups.

doi:10.1158/1078-0432.CCR-14-1324

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Article

Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2015

Merino Diana M, Shlien Adam, Villani Anita, Pienkowska Malgorzata, Mack Stephen, Ramaswamy Vijay, Shih David, Tatevossian Ruth, Novokmet Ana, Choufani Sanaa, Dvir Rina, Ben-Arush Myran, Harris Brent T, Hwang Eugene I, Lulla Rishi, Pfister Stefan M, Achatz Maria Isabel, Jabado Nada, Finlay Jonathan L, Weksberg Rosanna, Bouffet Eric, Hawkins Cynthia, Taylor Michael D, Tabori Uri, Ellison David W, Gilbertson Richard J, Malkin David

Abstract excerpt

PURPOSE: To investigate molecular alterations in choroid plexus tumors (CPT) using a genome-wide high-throughput approach to identify diagnostic and prognostic signatures that will refine tumor stratification and guide therapeutic options. EXPERIMENTAL DESIGN: One hundred CPTs were obtained from a multi-institutional tissue and clinical database. Copy-number (CN), DNA methylation, and gene expression signatures...

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PMID: 25336695
DOI: 10.1158/1078-0432.CCR-14-1324

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