Article
Genomic characterization of aggressiveness in pituitary neuroendocrine tumors.
Neuro-oncology - 1 Sept 2026
Benanteur Nesrine, Villa Chiara, Bioletto Fabio, Birtolo Maria Francesca, De Murat Daniel, Masliah-Planchon Julien, Gravrand Victor, Lebib Inès, Benkhellat Mounia, Boezennec Robin, Allassonnière Stéphanie, Letourneur Franck, Martin Yoann, Bonnet Serrano Fidéline, Jacob Julian, Calugaru Valentin, Barat Maxime, Dohan Anthony, Arrondeau Jennifer, Huillard Olivier, Raffin-Sanson Marie-Laure, Emile Jean François, Raverot Gérald, Libé Rossella, Guignat Laurence, Garcia Cyril, Groussin Lionel, Bertagna Xavier, Gaillard Stephan, Bertherat Jérôme, Jouinot Anne, Baussart Bertrand, Assié Guillaume
Abstract excerpt
BACKGROUND: Aggressive evolution of PitNETs is rare; metastatic spread is even more. Defining aggressiveness and malignancy is challenging, subsequently hard to predict, and to understand. The aim was to provide a molecular definition of aggressiveness using genomic approaches. METHODS: PitNETs from 206 patients were included. Associations between 9 clinicopathological features of aggressiveness and PitNETs'...
Read the complete abstract on PubMedTopics
- Humans
- Female
- Neuroendocrine Tumors