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Article

Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells.

Stem cell reports - 9 Nov 2021

Mukherjee Somdutta, French Deborah L, Gadue Paul

Abstract excerpt

Tbx3 has been identified as a regulator of liver development in the mouse, but its function in human liver development remains unknown. TBX3 mutant human pluripotent stem cell (PSC) lines were generated using CRISPR/Cas9 genome editing. TBX3 loss led to impaired liver differentiation and an upregulation of pancreatic gene expression, including PDX1, during a hepatocyte differentiation protocol. Other pancreatic...

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Identifiers

PMID: 34653400
DOI: 10.1016/j.stemcr.2021.09.004
PMCID: PMC8580886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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