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Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation

12 Jul 2013

Abstract excerpt

Developmental biology is challenged to reveal the function of numerous candidate genes implicated by recent genome-scale studies as regulators of organ development and diseases. Recapitulating organogenesis from purified progenitor cells that can be genetically manipulated would provide powerful opportunities to dissect such gene functions. Here we describe systems for reconstructing pancreas development,...

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PMID: 23852729
DOI: 10.1073/pnas.1304507110

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