Article

Integrative analysis of multi-omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancer

2021-01-22

Abstract excerpt

<title>Abstract</title> <p>Small cell lung cancer (SCLC) is highly invasive and lethal. Genomic studies are beginning to characterize its genetic determinants and heterogeneity. Here we performed RNA-Seq and whoe exome sequencing (WES) in 19 Chinese SCLC clinical tumor specimens. Integration with other two public cohorts (n = 129 for RNA-seq, n = 171 for WES), we carried out gene co-expression network analysis an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ff418438-bace-54ab-b9be-a0ea1caf66ac
DOI: 10.21203/rs.3.rs-148857/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative analysis of multi-omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancerDOI 10.21203/rs.3.rs-148857/v1Read

Integrative analysis of multi‐omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancerSemantic proximity Read

Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancerSemantic proximity Read

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signaturesSemantic proximity Read

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinomaSemantic proximity Read

Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancerSemantic proximity Read

Molecular subtyping of small-cell lung cancer based on mutational signatures with different genomic features and therapeutic strategies.Semantic proximity Read

Molecular Subtypes and Targeted Therapeutic Strategies in Small Cell Lung Cancer: Advances, Challenges, and Future PerspectivesSemantic proximity Read

Integrated Multi-Omics Analysis Identifies Key Genes and Drug Candidates in Non-Small Cell Lung CancerSemantic proximity Read

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancerSemantic proximity Read

Immune-Omics Networks of CD27, PD1, and PDL1 in Non-Small Cell Lung CancerSemantic proximity Read