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Accurate and comprehensive evaluation of O6‐methylguanine‐DNA methyltransferase promoter methylation by nanopore sequencing

23 May 2024

Abstract excerpt

AIMS: The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter region is essential in evaluating the prognosis and predicting the drug response in patients with glioblastoma. In this study, we evaluated the utility of using nanopore long-read sequencing as a method for assessing methylation levels throughout the MGMT CpG-island, compared its performance to established techniques and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38783575
DOI: 10.1111/nan.12984

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