Article

Long-read sequencing enables high-accuracy mitochondrial heteroplasmy detection in Parkinson’s disease

2026-06-15

Abstract excerpt

<h4>Background</h4> Low-frequency heteroplasmic mitochondrial DNA (mtDNA) variants are associated with aging and neurological diseases, including Parkinson’s disease (PD). Targeted deep mtDNA sequencing using PacBio HiFi long reads has the potential to resolve heteroplasmy across the full mitochondrial genome with high accuracy. <h4>Methods</h4> To validate Vega PacBio sequencing for detecting mtDNA heteroplasmy...

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Literature Corpus work: 5306f59e-ccb0-5286-b1d9-ec0fd0a4ef27
DOI: 10.64898/2026.06.11.26355258

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