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Article

Morphological and functional phenotyping of skeletal muscle and bone in the zQ175 knock-in mouse model of Huntington's disease.

Journal of Huntington's disease - 1 Feb 2026

Nateghi Behnaz, Lala Bouali Mohamed, Bouredji Zineb, Argaw Anteneh, Jayash Soher Nagi, Farquharson Colin, Frenette Jérôme, Hébert Sébastien S

Abstract excerpt

Background: Huntington's disease (HD) is a progressive neurodegenerative disorder primarily affecting the central nervous system (CNS). However, emerging evidence suggests that peripheral tissues, including skeletal muscle and bone, also undergo pathological changes contributing to disease burden. Objective: To characterize musculoskeletal impairments in the zQ175 knock-in (KI) mouse model of HD, through...

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Identifiers

PMID: 41148147
DOI: 10.1177/18796397251387208
PMCID: PMC12847460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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